You must pay sales taxes on all puppies.
To help breeders comply with the law, IDOR offers the following guidance:
Tax is due when the animal is sold to a purchaser who will keep it as a pet.
Tax is due if an animal is picked up at the breeder's Illinois facility, even if it will be immediately taken out of state.
This rate for Murphysboro IL is 7.25%
Information on taxes required for the State of Illinois.